11.41 p.m., 22nd August 2012, suburb of San José, Silicon Valley's modern dormitory town, California. A corpse is discovered in a baggage car in a suburban parking lot. It's a scientific researcher of Dutch extraction. It's just the beginning of a chain of murders who are to fully shock the life of Joe Brigati, a young Italo-canadian crime reporter who lives in Milan. With the complicity of a biography to write, he is to find accidentally himself in contact with a secret organization (called Orange Hands) who is trying to remove at the root the troubled international pharmaceutical business exalting scientific pureness. But it's nothing but the beginning of a wider and more silent worldwide revolution. Was the Orange Agent a fatal accident in Vietnam or was it a slaughter wanted by the U.S. army? A probe against time, leading the main character to solve by himself several murder cases between Milan and San Francisco.